自噬是一种多功能的细胞经由，在神经系统中进展要道作用。它看护大脑稳态，参与神经细胞的生成、训诲和存活，调遣神经干细胞的能量应用和微环境。自噬功能谢绝与多种神经系统疾病密切关连：在神经退行性疾病中，伴侣介导的自噬失调陪同神经元损害和归天；在缺血性脑卒中中，自噬被激活，但其约束是否有意仍存在争议；在脊髓损害中，自噬通过调控卵白质盘活影响干细胞气运，促进组织开垦。

自噬还参与胶质细胞（小胶质细胞、星形胶质细胞和少突胶质细胞）的调遣，影响神经发育、突触功能和脑代谢。脂质信号通路调控的自噬与低级纤毛功能互相作用，在神经发育和能量稳态中具有蹙迫意旨。调控自噬活性有望成为调治神经系统疾病的潜在战略。

因此，特精选本刊2023-2024年发表的自噬在神经系统疾病中的作用相干的热门综述著作5篇，供读者参阅。

(1) Autophagy in neural stem cells and glia for brain health and diseases

神经干细胞和神经胶质细胞中的自噬作用对大脑健康和疾病的影响

援用本文：Nagayach A, Wang C. Autophagy in neural stem cells and glia for brain health and diseases. Neural Regen Res. 2024;19(4):729-736.

正文聚首:

https://journals.lww.com/nrronline/fulltext/2024/04000/autophagy_in_neural_stem_cells_and_glia_for_brain.15.aspx

(2) Role of lipids in the control of autophagy and primary cilium signaling in neurons

脂质在适度神经元自噬和低级纤毛信号传导中的作用

援用本文：

Hernández-Cáceres MP, Pinto-Nuñez D, Rivera P, Burgos P, Díaz-Castro F, Criollo A, Yañez MJ, Morselli E. Role of lipids in the control of autophagy and primary cilium signaling in neurons. Neural Regen Res. 2024;19(2):264-271.

正文聚首:

https://journals.lww.com/nrronline/fulltext/2024/02000/role_of_lipids_in_the_control_of_autophagy_and.5.aspx

(3) Neuroprotective effects of chaperone-mediated autophagy in neurodegenerative diseases

伴侣介导的自噬在神经退行性疾病中的神经保护作用

援用本文：

Jia Q, Li J, Guo X, Li Y, Wu Y, Peng Y, Fang Z, Zhang X. Neuroprotective effects of chaperone-mediated autophagy in neurodegenerative diseases. Neural Regen Res. 2024 Jun 1;19(6):1291-1298.

正文聚首:

https://journals.lww.com/nrronline/fulltext/2024/06000/neuroprotective_effects_of_chaperone_mediated.33.aspx

(4) Sex-biased autophagy as a potential mechanism mediating sex differences in ischemic stroke outcome

有性别各异的自噬是介导缺血性脑卒中结局性别各异的潜在机制

援用本文：

Noh B, McCullough LD, Moruno-Manchon JF. Sex-biased autophagy as a potential mechanism mediating sex differences in ischemic stroke outcome. Neural Regen Res. 2023;18(1):31-37.

正文聚首:

https://journals.lww.com/nrronline/fulltext/2023/01000/sex_biased_autophagy_as_a_potential_mechanism.4.aspx

(5) Autophagy regulation combined with stem cell therapy for treatment of spinal cord injury

自噬调控长入干细胞疗法调治脊髓损害

援用本文：

Shen Y, Wang YP, Cheng X, Yang X, Wang G. Autophagy regulation combined with stem cell therapy for treatment of spinal cord injury. Neural Regen Res. 2023;18(8):1629-1636.

正文聚首:

https://journals.lww.com/nrronline/fulltext/2023/08000/autophagy_regulation_combined_with_stem_cell.1.aspx开yun体育网